Francesc Villarroya Selected Research

fibroblast growth factor 21

1/2021	Levels of β-klotho determine the thermogenic responsiveness of adipose tissues: involvement of the autocrine action of FGF21.
1/2021	The protective effect of fibroblast growth factor-21 in alcoholic cardiomyopathy: a role in protecting cardiac mitochondrial function.
1/2021	FGF21 serum levels are related to insulin resistance, metabolic changes and obesity in Mexican people living with HIV (PLWH).
1/2019	Oral administration of a new HRI activator as a new strategy to improve high-fat-diet-induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21.
1/2019	Fibroblast growth factor-21 protects against fibrosis in hypertensive heart disease.
10/2018	Aging is associated with increased FGF21 levels but unaltered FGF21 responsiveness in adipose tissue.
1/2018	Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection on the Fibroblast Growth Factor 21/β-Klotho System.
1/2018	Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease.
1/2018	Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency.
11/2017	Fgf21 is required for cardiac remodeling in pregnancy.

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Francesc Villarroya Research Topics

Disease

27	Obesity 07/2022 - 09/2012
27	Inflammation (Inflammations) 12/2021 - 03/2008
25	Insulin Resistance 07/2022 - 04/2007
23	Lipodystrophy 01/2022 - 02/2005
12	Infections 12/2012 - 01/2006
11	Type 2 Diabetes Mellitus (MODY) 01/2021 - 06/2006
9	Body Weight (Weight, Body) 07/2022 - 10/2014
8	Cardiomegaly (Heart Hypertrophy) 01/2021 - 05/2011
7	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 04/2010
6	Metabolic Diseases (Metabolic Disease) 07/2022 - 01/2017
6	Fibrosis (Cirrhosis) 01/2021 - 10/2016
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 01/2014
5	HIV Infections (HIV Infection) 01/2021 - 02/2005
5	Necrosis 01/2012 - 01/2006
4	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 01/2022 - 06/2008
4	Non-alcoholic Fatty Liver Disease 03/2021 - 01/2018
4	Heart Failure 01/2021 - 04/2015
4	Fatty Liver 10/2020 - 10/2016
4	Starvation 07/2013 - 09/2004
3	Dyslipidemias (Dyslipidemia) 01/2022 - 11/2010
3	Hepatocellular Carcinoma (Hepatoma) 03/2021 - 10/2016
3	Weight Gain 01/2021 - 10/2016
3	Weight Loss (Weight Reduction) 10/2020 - 12/2015
3	Morbid Obesity 03/2020 - 01/2020
3	Glucose Intolerance 01/2019 - 10/2016
3	Heart Diseases (Heart Disease) 01/2019 - 01/2015
3	Lipomatosis 01/2015 - 04/2004
3	Hypertrophy 01/2013 - 05/2011
2	Atherosclerosis 01/2021 - 01/2015
2	Overweight 01/2021 - 01/2021
2	Hyperglycemia 01/2021 - 03/2020
2	Hypoxia (Hypoxemia) 10/2020 - 10/2014
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2020 - 01/2018
2	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2017 - 06/2008
2	Neoplasms (Cancer) 10/2016 - 06/2012
2	Hyperlactatemia 12/2009 - 03/2007
1	Endotoxemia 07/2022

Drug/Important Bio-Agent (IBA)

26	fibroblast growth factor 21IBA 01/2021 - 11/2010
13	Proteins (Proteins, Gene)FDA Link 03/2022 - 03/2007
13	Glucose (Dextrose)FDA LinkGeneric 12/2021 - 11/2010
11	AdipokinesIBA 02/2020 - 01/2006
10	Insulin (Novolin)FDA Link 07/2022 - 06/2006
10	Biomarkers (Surrogate Marker)IBA 01/2021 - 11/2010
9	Messenger RNA (mRNA)IBA 03/2022 - 10/2006
9	LipidsIBA 03/2021 - 01/2009
7	Fatty Acids (Saturated Fatty Acids)IBA 01/2022 - 06/2008
7	CytokinesIBA 04/2021 - 01/2007
6	Mitochondrial DNA (mtDNA)IBA 01/2018 - 11/2006
5	EnzymesIBA 12/2021 - 05/2012
5	NucleosidesIBA 08/2011 - 02/2005
4	Metformin (Glucophage)FDA LinkGeneric 07/2022 - 01/2018
4	Triglycerides (Triacylglycerol)IBA 03/2022 - 10/2010
4	Hormones (Hormone)IBA 12/2018 - 07/2013
4	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 01/2018 - 01/2010
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018 - 01/2007
4	Pharmaceutical PreparationsIBA 01/2017 - 07/2007
4	Stavudine (Zerit)FDA LinkGeneric 01/2014 - 04/2010
4	Reverse Transcriptase InhibitorsIBA 06/2012 - 02/2005
3	LeptinIBA 07/2022 - 01/2006
3	C-Reactive ProteinIBA 01/2022 - 01/2015
3	AdiponectinIBA 11/2021 - 01/2006
3	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2021 - 05/2011
3	Sirtuin 3IBA 10/2020 - 05/2012
3	AntioxidantsIBA 01/2020 - 04/2015
3	Histones (Histone)IBA 01/2020 - 01/2016
3	Interleukin-6 (Interleukin 6)IBA 10/2016 - 01/2010
3	Sirtuin 1IBA 11/2015 - 05/2011
3	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2015 - 05/2012
3	Lactic Acid (Lactate)FDA LinkGeneric 10/2014 - 03/2007
3	stavudine triphosphateIBA 01/2013 - 04/2010
2	Palmitic Acid (Hexadecanoic Acid)IBA 12/2021 - 01/2020
2	Anthocyanins (Anthocyanin)IBA 12/2021 - 01/2020
2	ChemokinesIBA 01/2021 - 01/2020
2	Pioglitazone (Actos)FDA Link 01/2021 - 01/2018
2	Betaine (C.B.B.)FDA Link 01/2021 - 01/2016
2	Spironolactone (Aldactone)FDA LinkGeneric 01/2021 - 01/2018
2	NAD (NADH)IBA 01/2021 - 06/2012
2	HDL CholesterolIBA 01/2021 - 12/2012
2	Oncostatin MIBA 03/2020 - 01/2017
2	Growth Differentiation Factor 15IBA 01/2020 - 01/2016
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2018 - 11/2014
2	lipopolysaccharide-binding proteinIBA 10/2016 - 11/2013
2	Peptides (Polypeptides)IBA 03/2016 - 09/2015
2	LDL CholesterolIBA 01/2015 - 11/2010
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2015 - 11/2014
2	Interleukin-18 (Interleukin 18)IBA 10/2013 - 10/2012
2	ResveratrolIBA 09/2013 - 05/2011
2	Thymidylate SynthaseIBA 01/2013 - 04/2011
2	PPAR gammaIBA 10/2012 - 11/2006
1	SecretagoguesIBA 07/2022
1	Peptide Hormones (Polypeptide Hormones)IBA 07/2022
1	Estrogens (Estrogen)FDA Link 07/2022
1	Lipase (Acid Lipase)FDA Link 03/2022
1	Glycerol (Glycerine)FDA LinkGeneric 03/2022
1	Nonesterified Fatty Acids (NEFA)IBA 03/2022
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2022

Therapy/Procedure

17	Highly Active Antiretroviral Therapy (HAART) 01/2022 - 04/2004
11	Therapeutics 10/2021 - 02/2005
3	Bariatric Surgery 01/2020 - 01/2017
2	Transplantation 09/2013 - 01/2013